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proline metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
2-oxoglutarate + L-ornithine <=> L-glutamate + 5-amino-2-oxopentanoate 2.6.1.8 2,5-diaminovalerate transaminase

L-ornithine + 2-oxoglutarate <=> L-glutamate + L-glutamate_5-semialdehyde 2.6.1.11 acetylornithine transaminase
2.6.1.13 ornithine aminotransferase
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.81 succinylornithine transaminase




L-proline + acceptor <=> L-pyrroline-5-carboxylate + reduced_acceptor 1.5.5.2 proline dehydrogenase
1.5.99.B2


5-amino-2-oxopentanoate <=> DELTA1-pyrroline-2-carboxylate + H2O + H+ 0.0.0.0

L-proline + NADP+ <=> L-pyrroline-5-carboxylate + NADPH + H+ 1.5.1.2 pyrroline-5-carboxylate reductase

ATP + L-proline + tRNAMet <=> AMP + diphosphate + L-prolyl-tRNAPro 6.1.1.15 proline---tRNA ligase
6.1.1.17 glutamate---tRNA ligase


H+ + H2O + L-pyrroline-5-carboxylate <=> L-glutamate_5-semialdehyde 0.0.0.0

L-glutamate_5-semialdehyde + H2O + NAD+ <=> L-glutamate + NADH + H+ 1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.41 glutamate-5-semialdehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase




L-glutamate + ATP <=> L-5-glutamyl_phosphate + ADP 2.7.2.11 glutamate 5-kinase

D-proline + acceptor <=> DELTA1-pyrroline-2-carboxylate + reduced_acceptor + H+ 1.5.99.13 D-proline dehydrogenase

L-proline <=> D-proline 5.1.1.4 proline racemase
5.1.1.8 4-hydroxyproline epimerase


L-glutamate_5-semialdehyde + phosphate + NADP+ <=> L-5-glutamyl_phosphate + NADPH + H+ 1.2.1.41 glutamate-5-semialdehyde dehydrogenase

D-proline + NADH <=> 5-Aminopentanoate + NAD+ 1.21.4.1 D-proline reductase

L-proline + NADP+ <=> DELTA1-pyrroline-2-carboxylate + NADPH + H+ 1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
1.5.1.21 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
1.5.1.25 thiomorpholine-carboxylate dehydrogenase
1.5.1.49 1-pyrroline-2-carboxylate reductase [NAD(P)H]




L-proline + FAD <=> L-pyrroline-5-carboxylate + FADH2 1.5
1.5.5.2 proline dehydrogenase
1.5.8
1.5.99.B2




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